2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0001S
    Lurasidone Metabolite 14283-d8
    Lurasidone Metabolite 14283-d8 is the deuterium labeled Lurasidone Metabolite 14283, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14283-d<sub>8</sub>
  • HY-32350S
    Ercalcitriol-13C,d3
    Ercalcitriol-13C,d3 is the 13C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.
    Ercalcitriol-<sup>13</sup>C,d<sub>3</sub>
  • HY-101108S
    Tazarotenic acid-d6
    Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-d<sub>6</sub>
  • HY-131283
    8-Demethyl Ivabradine
    8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    8-Demethyl Ivabradine
  • HY-131281
    Ivabradine impurity 1
    Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    Ivabradine impurity 1
  • HY-138149
    2-epi-Abamectin
    2-epi-Abamectin is a degradation product of Abamectin. It is toxic to the two-spotted spider mite in a contact assay with an LC50 value of 4 ppm, which is approximately 100-fold less potent than abamectin.
    2-epi-Abamectin
  • HY-W748688
    N4-Acetylsulfamethoxazole-13C6
    N4-Acetylsulfamethoxazole-13C6 (Acetylsulfamethoxazole-13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections.
    N4-Acetylsulfamethoxazole-<sup>13</sup>C<sub>6</sub>
  • HY-17366AR
    Clozapine N-oxide dihydrochloride (Standard)
    Clozapine N-oxide (dihydrochloride) (Standard) is the analytical standard of Clozapine N-oxide (dihydrochloride). This product is intended for research and analytical applications. Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide dihydrochloride (Standard)
  • HY-133794R
    Dasatinib N-oxide (Standard)
    L-Ascorbic acid (GMP Like) (Standard) is the analytical standard of L-Ascorbic acid (GMP Like). This product is intended for research and analytical applications. L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.
    Dasatinib N-oxide (Standard)
  • HY-I0736S
    Isonicotinic acid-d4
    		98.12%
    Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C.
    Isonicotinic acid-d<sub>4</sub>
  • HY-143970S
    Ivabradine impurity 7-d6
    Ivabradine impurity 7-d6 is the deuterium labeled Ivabradine impurity 7.
    Ivabradine impurity 7-d<sub>6</sub>
  • HY-136344
    Simvastatin Acyl-β-D-glucuronide
    Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    Simvastatin Acyl-β-D-glucuronide
  • HY-N8269
    Rivularin
    Rivularin (Skullcapflavone) is a flavonoid that can be found in Radix scutellariae.
    Rivularin
  • HY-15876R
    Clopidogrel thiolactone (Standard)
    Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Clopidogrel thiolactone (Standard)
  • HY-114794R
    Desglymidodrine (Standard)
    Desglymidodrine (Standard) is the analytical standard of Desglymidodrine. This product is intended for research and analytical applications. Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure.
    Desglymidodrine (Standard)
  • HY-43670A
    Chlorthalidone impurity ammonium
    		99.93%
    Chlorthalidone impurity (ammonium) is the ammonium salt form of the metabolite of Chlorthalidone (HY-15833).Chlorthalidone is a thiazide diuretic used in the study of hypertension.
    Chlorthalidone impurity ammonium
  • HY-131271
    Febuxostat impurity 6
    Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 6
  • HY-N2304
    3-O-Methyl-6β-naltrexone
    		Chemical
    3-O-Methyl-6β-naltrexone is a metabolite of Naltrexone.
    3-O-Methyl-6β-naltrexone
  • HY-109583
    4-Oxofenretinide
    4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
    4-Oxofenretinide
  • HY-169768
    (E/Z)-Etherolenic acid
    (E/Z)-Etherolenic acid is a divinyl ether oxylipin and is a metabolite of Linolenic acid.
    (E/Z)-Etherolenic acid
Cat. No. Product Name / Synonyms Application Reactivity